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Researcher

Prof. dr. J. (Jolanda) Kluin MD PhD

Head of Department Cardiothoracic Surgery, Principal investigator

  • Department
  • Cardiothoracic Surgery
  • Focus area
  • Development of new heart valve prosthesis, Hybrid total artificial heart development, Tissue engineering , Modern imaging (VR, AR), Large databases enabling personalized care

About Prof. dr. J. (Jolanda) Kluin MD PhD

Introduction

Professor Jolanda Kluin studied medicine in Rotterdam where she also did her PhD and training in cardiothoracic surgery. After that, she worked as a consultant in Utrecht and Amsterdam. She served as the chair of the European Association EACTS Women in Cardiothoracic Surgery Committee and is associate editor of the European heart Journal. 

Her clinical work and surgical focus is mainly on valve reconstruction, endocarditis and the complex type of (redo) operations. Her research in translational cardiothoracic surgery includes, amongst others, development of new (e.g., tissue engineered) heart valves and the development of a hybrid, soft robotic artificial heart, virtual reality and other modern imaging tools, always with a view to this work ending up in helping the patient. She was principal investigator of the FET-Open Hybrid Heart project and is principal investigator of the NWA-ORC Holland Hybrid Heart project. She is visiting professor of Brigham and Women’s Hospital Boston and fellow of the European Society of Cardiology. She advises the Dutch government as member of the Advisory Council for Science, Technology and Innovation. 

Field(s) of expertise

Research lines include:

  • Translational research on the development of new heart valve prostheses (both tissue engineered as synthetic) and the development of a soft robotic total artificial heart from bench to bed.
  • Modern imaging to improve outcomes in cardiothoracic surgery. This includes the use of VR and AR in preoperative planning, postoperative anxiety and pain reduction, and education.
  • The use of big data from large databases to improve decision making in cardiothoracic surgery with the focus on heart valve disease. 

Education and career

Professor Kluin studied medicine at Erasmus University Rotterdam (Medical doctor degree cum laude), In 1999 she graduated cum laude as PhD in general surgery. She was trained as cardiothoracic surgeon at Erasmus MC Rotterdam and was a staff surgeon for 7 years at UMC Utrecht and Amsterdam UMC. Since 2023 she is head of the department of Cardiothoracic Surgery at Erasmus Medical Centre Rotterdam.

Publications

Clinical Decision Making

  • 2024: How microsimulation translates outcome estimates to patient lifetime event occurrence in the setting of heart valve disease.

    Notenboom, M. L., Rhellab, R., Etnel, J. R. G., Huygens, S. A., Hjortnaes, J., Kluin, J., Takkenberg, J. J. M., & Veen, K. M.
    In: European journal of cardio-thoracic surgery 2024;65(3): ezae087.

  • 2024: The future of valvular heart disease assessment and therapy. Sengupta, P. P., Kluin, J., Lee, S. P., Oh, J. K., & Smits, A. I. P. M. 
    In:  Lancet 2024;403(10436):1590–1602.
  • 2020: ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation.

    Collet JP, Thiele H, Barbato E, Barthélémy O, Bauersachs J, Bhatt DL, Dendale P, Dorobantu M, Edvardsen T, Folliguet T, Gale CP, Gilard M, Jobs A, Jüni P, Lambrinou E, Lewis BS, Mehilli J, Meliga E, Merkely B, Mueller C, Roffi M, Rutten FH, Sibbing D, Siontis GCM; ESC Scientific Document Group (Review Committee).
    In: European Heart Journal 2021;42:1289-1367.

  • 2020: ESC Guidelines for the management of adult congenital heart disease.

    Baumgartner H, De Backer J, Babu-Narayan SV, Budts W, Chessa M, Diller GP, Lung B, Kluin J, Lang IM, Meijboom F, Moons P, Mulder BJM, Oechslin E, Roos-Hesselink JW, Schwerzmann M, Sondergaard L, Zeppenfeld K; ESC Scientific Document Group.
    In: European Heart Journal 2021;42:563-645.

  • 2018: ESC Guidelines for the management of cardiovascular diseases during pregnancy.

    Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, Blomström-Lundqvist C, Cífková R, De Bonis M, Iung B, Johnson MR, Kintscher U, Kranke P, Lang IM, Morais J, Pieper PG, Presbitero P, Price S, Rosano GMC, Seeland U, Simoncini T, Swan L, Warnes CA; ESC Scientific Document Group (Review Committee).
    In: European Heart Journal 2018;39:3165-3241.

  • 2017: Does the use of a decision aid improve decision making in prosthetic heart valve selection? A multicenter randomized trial.

    Korteland NM, Ahmed Y, Koolbergen DR, Brouwer M, de Heer F, Kluin J, Bruggemans EF, Klautz RJ, Stiggelbout AM, Bucx JJ, Roos-Hesselink JW, Polak P, Markou T, van den Broek I, Ligthart R, Bogers AJ, Takkenberg JJ.
    In: Circulation Cardiovascular Quality Outcomes 2017;10: e003178.

    Imaging

  • 2024: Virtual Reality for Pain and Anxiety Management in Cardiac Surgery and Interventional Cardiology.

    El Mathari, S., Hoekman, A., Kharbanda, R. K., Sadeghi, A. H., de Lind van Wijngaarden, R., Götte, M., Klautz, R. J. M., & Kluin, J.
    In: Management in Cardiac Surgery and Interventional Cardiology 2024;3(2): 100814.

  • 2018: Advanced cardiac MRI techniques for evaluation of left-sided valvular heart disease.

    Blanken CPS, Farag ES, Boekholdt SM, Leiner T, Kluin J, Nederveen AJ, van Ooij P, Planken RN.
    In: Journal of Magnetic Resonance Imaging 2018;48:318-329.

  • 2013: Automated 3D analysis of pre-procedural MDCT to predict annulus plane angulation and C- arm positioning: benefit on procedural outcome in patients referred for TAVR.

    Samim M, Stella PR, Agostoni P, Kluin J, Ramjankhan F, Budde RP, Sieswerda G, Algeri E, van Belle C, Elkalioubie A, Juthier F, Belkacemi A, Bertrand ME, Doevendans PA, van Belle E.
    In: Journal of the American College of Cardiology Cardiovascular Imaging 2013;6:238-248.

  • 2006: Preoperative computed tomography coronary angiography to detect significant coronary artery stenosis in patients referred for valve surgery.

    Meijboom WB, Mollet NR, van Mieghem CAG, Kluin J, Weustink AC, Pugliese F, Vourvouri E, Cademartiri F, Bogers AJ, Krestin GP, de Feyter P.
    In: Journal of the American College of Cardiology 2006;48:1658-1665.

    Translational (development new heart valves, tissue engineering)

  • 2023: Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold.

    Yacoub MH, Tseng YT, Kluin J, Vis A, Stock U, Smail H, Sarathchandra P, Aikawa E, El-Nashar H, Chester AH, Shehata N, Nagy M, El-Sawy A, Li W, Burriesci G, Salmonsmith J, Romeih S, Latif N.
    In: Commun Biol. 2023 Oct 7;6(1):1017.

  • 2020: In situ remodeling overrules bioinspired scaffold architecture of supramolecular elastomeric tissue-engineered heart valves.

    Uiterwijk M, Smits AIPM, van Geemen D, van Klarenbosch B, Dekker S, Cramer MJ, van Rijswijk JW, Lurier EB, Di Luca A, Brugmans MCP, Mes T, Bosman AW, Aikawa E, Gründeman PF, Bouten CVC, Kluin J.
    In: Journal of the American College of Cardiology Basic to Translational Science 2020;5:1187-1206.

  • 2017: In situ tissue engineering using a bioresorbable elastomeric implant – from material design to 12 months follow-up in sheep.

    Kluin J, Talacua H, Smits AI, Emmert MY, Brugmans MC, Fioretta ES, Dijkman PE, Sontjens SH, Duijvelshof R, Dekker S, Janssen-van den Broek MW, Lintas V, Hoerstrup SP, Janssen HM, Dankers PY, Baaijens FP, Bouten CV.
    In: Biomaterials 2017;125:101-107.

  • 2016: Early in situ cellularization of a supramolecular vascular graft is modified by synthetic stromal cell derived factor 1α derived peptides.

    Muylaert DEP, van Almen GC, Talacua H, Fledderus JO, Kluin J, Hendrikse SIS, van Dongen JLJ, Sijbesma E, Bosman AW, Mes T, Thakkar SH, Smits AIPM, Bouten CVC, Dankers PYW, Verhaar MC.
    In: Biomaterials 2016;76:187-195.

  • 2015: In situ tissue engineering of functional small-diameter blood vessels by host circulating cells only.
    Talacua H, Smits AI, Muylaert DE, van Rijswijk JW, Vink A, Verhaar MC, Driessen-Mol A, van Herwerden LA, Bouten CV, Kluin J, Baaijens FP.
    In: Tissue Engineering Part A 2015;21:2583-2594

Teaching activities

She holds the BKO certificate for teaching. She supervises 20 PhD students and teaches medical students, trainees and PhDs. She is lecturer on several (inter)national meetings of scientific and medical societies.

Other positions

  • 2003 - 2007: Member Trainees Resource Working Group of the European Association for CardioThoracic Surgery
  • 2004 - 2006: Secretary Juniorkamer Dutch Society of Cardiothoracic Surgery
  • 2009 - 2013: Member Committee Professional Interests Dutch Society of Cardiothoracic Surgery
  • 2011 - 2014: Member Steyn Parvé Actueel Program Committee UMC Utrecht
  • 2012 - present: Member Aortic Valve Repair Working Group of the Heart Valve Society 
  • 2012 - 2022: Member working group Heart Valve Decision Support of the Dutch Society of Cardiothoracic Surgery 
  • 2013 - 2014: Board member Utrecht Cardiovasculair Cohort
  • 2013 - 2015: Member Dutch Mitral Working Group
  • 2013 - 2015: Board Member Collegium Chirurgicum Neerlandicum
  • 2014 - 2014: Member Concilium and Plenaire Visitatie Committee of the Dutch Society of Cardiothoracic Surgery 
  • 2014 - 2016: Member Domain of Acquired Cardiac Disease of the European Association for CardioThoracic Surgery
  • 2016 - 2019: Board member (treasurer) Nucleus Cardiothoracic Surgery of the European Society of Cardiology
  • 2017 - present: Advisory Board member European Society of Cardiovascular and Endovascular Surgery
  • 2018 - present: Chair of the Board of AVIATOR international registry for aortic valve reconstruction
  • 2018 - 2020: Member working group Nomination and Talent AMC-VUmc
  • 2020 - 2023: Vice-chair Committee Talent and Appointments AMC-VUmc
  • 2020 - present: Chair of the Board of the Royal Dutch Society of Medicine (KNMG) Utrecht district
  • 2020 - 2024: Chair of the European Association for CardioThoracic Surgery (EACTS) Women’s Committee 
  • 2021 - present: Member Supervisory Board Foundation (Raad van Toezicht) Delta de Bilt, Primary Schools Utrecht district
  • 2022 - present: Member Board of Directors of the Heart Valve Society
  • 2022 - present: Member Advisory Councel for Science, Technology and innocation, AWTI (Adviesraad Wetenschap Technology en Innovatie), an independent body which advises the Dutch government and parliament on matters related to science, technology and innovation

Grants and awards

Grants

  • 2004 – 2007: Foundation to stimulate Surgical Cancer Research in Rotterdam (PI; 50 kEuro)

  • 2007 – 2011: TeRM Smartmix (Translational Regenerative Medicine), Heart valve tissue engineering towards clinical practice (total funding 1.786 kEuro; Kluin 318 kEuro)

  • 2009 – 2013: Dutch Heart Foundation, Heart valve tissue engineering (PI; 246 kEuro)

  • 2010 – 2014: BBM (BioMedical Materials program), iValve (total funding 3.997 kEuro; Kluin 348 kEuro)

  • 2011 – 2014: Netherlands Heart Foundation (Dekker grant Drs. J. Hjortnaes, 69 kEuro)

  • 2011 – 2020: AGIKO ZonMW, Calcific aortic valve disease: revealing mechanisms (PI; 64 kEuro)

  • 2012 – 2014: BMM/Dutch Heart Foundation, extra work package for iValve (total funding 240 kEuro; Kluin 120 kEuro)

  • 2013: Edwards, research stipendium (PI; 35 kEuro)

  • 2013: Seeding and travel grants Program Committee Circulatory Health UMC Utrecht, asymptomatic mitral valve regurgitation trial (PI; 33, 10 and 5 kEuro)

  • 2013 – 2021: CardioVascular Research The Netherlands (CVON), 1Valve (PI; total funding 5.000 kEuro, Kluin 2.100 kEuro)

  • 2015 – 2018: AMC PhD grant Frederiek de Heer (AVIATOR: international registry for aortic valve repair, PI; 120 kEuro)

  • 2015 – 2018: AMC PhD grant Jan Willem van Rijswijk (heart valve biology and pathology, PI; 120 kEuro)

  • 2015 – 2018: Appelvink PhD grant Emile Farag (4D flow MRI in congenital heart disease, PI; 180 kEuro)

  • 2017 – 2018: ZonMW 3V Kennisinfrastructure (PI; 14 kEuro)

  • 2017 – 2023: EU Horizon 2020 FET (Future and Emerging Technology) grant, Hybrid Heart (PI; 3.036 kEuro)

  • 2019: EU Intellectual Property Booster Services (PI; 50kEuro) 

  • 2020 – 2023: AMC PhD Scholarship (PI; 216 kEuro)

  • 2020: Seeding fund of the British Heart Foundation Big Beat Challenge (PI; 59 kEuro)

  • 2021: Stimulant Voucher AmsterdamUMC for Virtual Reality Lab (PI; 2 kEuro) 

  • 2023-2030: NWA-ORC grant Holland Hybrid Heart (PI; 11.000 kEuro)

Awards 

  • 1997: Resident Award of the American Society for laser Medicine and Surgery
  • 1998: Prix de Communication Scientifique d’Université de Nantes
  • 1998: Second Prize of the Netherlands Laser Association
  • 1999: “Schoemaker Prize” for the best surgical PhD thesis of the Netherlands Society of Surgery
 

Granted Patents

  • Prosthetic valve and method of making a prosthetic valve: 30230-WO-PCT
  • Method of making a prosthetic heart valve and valve obtained therewith: 30231-WO-PCT and 30232-WO-PCT and 30259-WO-PCT 
  • “Muscolo cardiaco artificiale”: IT2020000015208
  • An implantable artificial heart: PCT/IB2023/057618

     

Related

Departments and research centers

Cardiothoracic Surgery