Department

Orthopaedics and Sports Medicine

Our goal is to keep people mobile as long as possible by improving therapeutic interventions. We study risk factors and (molecular) processes of skeletal growth & development disorders, sport & traumatic injuries and osteoarthritis.

About our Department

Our research

The mission of the department of Orthopedics and Sports Medicine is: “to promote sustainable improvement in physical activity, empowering individuals to lead healthier lives “. By implementing a comprehensive strategy, we aim to maintain global leadership in the field, focused on sustainable mobility and physical activity of the population, prevention of musculoskeletal (MSK) disorders, accessible and equal care for all patient groups, and innovative and cost-effective surgical and non-surgical treatments to optimize the use of the critical capacity of care.
The research strategy of our department is focused in 4 research lines:

‘Prevention and early treatment of osteoarthritis’

‘Musculoskeletal growth and development’

‘Exercise as medicine and healthcare for sports injuries’

‘Technology for Complex Musculoskeletal reconstructions’

Principal Investigators

Head of Department: Mevr. Prof. dr. D. Eygendaal

Osteoarthritis
Basic research
Prof. dr. G.J.V.M. van Osch

Clinical research
Prof. dr. S.M.A. Bierma-Zeinstra
Prof.dr.ir. J. Harlaar

Prof.dr. J.B.J. van Meurs
Dr. M. Reijman
Dr. D.E. Meuffels
Dr. J. van Oldenrijk
Dr. J. Colaris
Dr. R. Agricola

Skeletal growth and development
Basis research
Prof. dr. G.J.V.M. van Osch
Dr. R. Narcisi

Clinical research
Prof. dr. S.M.A. Bierma-Zeinstra
Dr. M. Reijman
Prof. dr. ir. J. Harlaar
Dr. R. Agricola

Sports- and traumatic injuries
Basic research
Prof. dr. G.J.V.M. van Osch
Dr. R. Narcisi

Clinical research
Prof. dr. S.M.A. Bierma-Zeinstra
Dr. M. Reijman
Prof. dr. ir. J. Harlaar
Dr. D.E. Meuffels
Dr. J. Colaris
Dr. R.J. de Vos
Dr. T. Piscaer

Research lines

‘Prevention and early treatment of osteoarthritis’

‘Musculoskeletal growth and development’

‘Exercise as medicine and healthcare for sports injuries’

‘Technology for Complex Musculoskeletal reconstructions’

Projects

At Home screening for scoliosis

GRIPP

Golf Related Injury Prevention Program (GRIPP) intervention.

HAT-project

Research project: To study whether a high volume injection without corticosteroids improves clinical outcome in addition to usual care for adults with chronic midportion Achilles tendinopathy.

Healthy Joints

iCELL

IC-Move

Description will follow

IMPAcT-project

To develop a 'Mobility and Physical activity Telemonitoring System' and determine its (cost-) effectiveness

INSPIRE-project

To examine the effect of a multifactorial, online injury prevention programme on the number of running-related injuries (RRIs) in recreational runners.

INTOarthritis

Identifying New Treatment targets for Osteoarthritis using multi-omic data and next generation personalised human in vitro models

JOCD

Evaluation of juvenile osteochondritis dissecans in a population-based cohort and its association with multiple potential risk factors.

JUMPER-project

Research project: To compare the effectiveness of progressive tendon-loading exercises (PTLE) with eccentric exercise therapy (EET) in patients with patellar tendinopathy.

LoaD

Microfet2 Stabilizer project

Development of a stabillizer for the Microfet2, a hand-held dynamometer to measure accurately and reliable the force of quadriceps muscle. This project is in collaboration with Create4Care and the department of Medical Technology of the Erasmus MC

OAinject

Rotate-project

Research towards individualized treatment recommendation in patients with an anterior cruciate ligament rupture.

SUSPECT-study

Patients with a clinically suspected scaphoid fracture and normal initial radiographs are treated with 2 weeks below-elbow cast. However, only 10% of these patients has eventually a scaphoid fracture. Therefore, we are treating most patients unnecessary.

Telefysio-Project

Telefysio is a long-term phased dynamic project to develop, implement and evaluate a digital physical therapy application to be used before, during, and after hospitalization.

Treatment of Achilles tendinopathy – a living systematic review and network meta-analysis

Research project: Evaluation of the comparative effectiveness of all available treatments for Achilles tendinopathy.

TXA-RCT

Effect of tranexamic acid on intraoperative blood loss in paediatric osteotomies around the hip: a double-

WalkWell Gait reTrainer

The project evaluates a wearable device, the WalkWell Gait reTrainer, for personalized gait retraining to improve daily life for knee osteoarthritis patients

World COACH Consortium

Worldwide collaboration of prospective studies to advance the principles of hip osteoarthritis in order to discover personalized prevention and treatment modalities

Doctoral theses

2024

Verschueren J (2024 June) Unloading therapy for medial knee osteoarthritis: Clinical outcomes and quantitative imaging considerations. Promotor: Prof. S.M.A. Bierma-Zeinstra, MD, PhD & Prof. E. Oei, MD, PhD, Copromotor: M. Reijman, PhD Pure Eur.nl

Wesdorp M.A. (2024, January) Promoting endogenous repair in osteochondral defects: Exploring therapeutic strategies and the impact of inflammation. Prom/Coprom: Prof.dr. G.J.V.M. van Osch, Prof. dr. J.A.N. Verhaar, Dr. R. Narcisi. Pure Eur.nl

Willems J.A. (2024 April) Bone, Union and Osteoarthritis. Prom/Coprom: Prof.dr. S.M.A. Bierma-Zeinstra, D.E. Meuffels, Dr. O. van der Jagt Pure Eur.nl

2023

Rooij de J.D. (2023, January) Nucleoplasty: A new treatment option for cervical radicular pain due to a disc herniation.Pure.Eur.nl

Kuijk K.S.R. (2023, March): Cruciate ligament rupture and the role of radiological knee shape. Prom/Coprom: Prof.dr. S.M.A. Bierma-Zeinstra, D.E. Meuffels.Pure.Eur.nl

Voskamp C. (2023, April): Cartilage Tissue Engineering. Prom/Coprom: Prof.dr. G.J.V.M. van Osch, Dr. R. Narcisi. Pure.Eur.nl

Pkric A. (2023, January): Advancement in total elbow arthroplasty care. Prom/Coprom: Prof.dr. D. Eygendaal, Dr. B. The, Dr. C.J.A. van Bergen. Pure.eur.nl

2022

Ferrao Blanco M. 2022, October) Pharmacolocal treatments for osteoarthritis - Emerging therapeutic strategies targeting chondrocyte hypertrophy and inflammation. Prom/Coprom: Prof.dr. G.J.V.M. van Osch, Dr. R. Narcisi. Pure.eur.nl

van Egmond J. (2022, October) Optimizing Fast-Track Protocols for Primary Total Knee Arthroplasty. Rotterdam: Erasmus University Rotterdam. PRom/Coprom: Prof.dr. J.A.N. Verhaar, Dr. N.M.C. Mathijssen. Pure.eur,nl

2021

Leijs, M. (2021, December). Intra-Articular Application of Mesenchymal Stem Cell Therapy for Osteoarthritis — The Next Step: Optimization of Therapeutic Capacity and Applicability. Prom/Coprom: Prof.dr. G.J.V.M. van Osch, Dr. M. Bernsen, Dr. P.K. Bos. https://repub.eur.nl/pub/137032

Eggerding, V. (2021, June). Optimal treatment for patients after anterior cruciate ligament rupture. Prom/Coprom: Prof.dr. S.M. Bierma-Zeinstra, Dr. M. Reijman, Dr. D.E. Meuffels. https://repub.eur.nl/pub/135515

van Klij, P. (2021, March 10). The development of the non-perfect hip in young athletes. Prom/Coprom: Prof.dr. J.A.N. Verhaar, Dr. R. Agricola.Repub P. van Klij, embargo

Vainieri, ML (2021, February 18). Towards Cartilage Regeneration: Biomaterial-Assisted Cell-Free Approach in a Physiological Joint-like Environment. Prom/Coprom: Prof.dr. G.J.V.M. van Osch. https://repub.eur.nl/pub/131288

Van der Vlist, AC (2021, January 20) Achilles Tendinopathy: risk factors, imaging, and treatment. Prom/Coprom: Prof.dr. J.A.N. Verhaar, Dr. R.J. de Vos. https://repub.eur.nl/pub/133300

2020

Fokkema, T. (2020, December 2). Prognosis and Prevention of Injuries in Recreational Runners. Prom/Coprom: Prof.dr.S.M. Bierma-Zeinstra, M. van Middelkoop, R.J. de Vos https://repub.eur.nl/pub/124642

Tolk, JJ (2020, June 2). Expectations and Outcome in Knee and Hip Arthroplasty. Prom/Coprom: S.M. Bierma-Zeinstra, M. Reijman, R.P.A. Janssen. https://repub.eur.nl/pub/127241

Eijgenraam SM (2020, January 22). The Meniscus Matters - Novel insights into imaging and treatment of meniscal pathology. Prom/coprom: Prof. S.M.A. Bierma-Zeinstra, Dr. E.H.G. Oei, Dr. M. Reijman en Dr. D.E. Meuffels https://repub.eur.nl/pub/120794

Suijkerbuijk MAM (2020, January 8) Hamstring Tendon Regeneration Following Harvest for Anterior Cruciate Ligament Reconstruction Prom/coprom: Prof.dr.G.J.V.M. van Osch, Dr. D.E. Meuffels, Dr. Y.M. Bastiaansen-Jenniskens https://repub.eur.nl/pub/121752

2019

v Oldenrijk J. (2019, May 21) Short Incisions and Short Stems in Total Hip Arthroplasty. Prom/coprom: Prof.dr.C.N. van Dijk, dr. M.U. Schafroth, dr. R.W. Poolman https://www.orthopeden.org/downloads/654/proefschrift-jakob-van-oldenrijk.pdf?view=active

Fahmy-Garcia S. (2019, May 2019) Towards in situ bone tissue engineering : an injectable system for protein delivery. Prom/coprom: Prof.dr. G.J.V.M. van Osch, Prof. Dr.J.P.T.M. van Leeuwen, Dr. E. Farrell, Dr. M. van Driel https://repub.eur.nl/pub/116479

Mumcuoglu, Z. D. (2018, May 9). Development of an injectable slow release system for bone morphogenetic protein-2. Prom./coprom.: Prof. Dr. G.J.V.M. van Osch & S.G. Kluijtmans. https://repub.eur.nl/pub/105787

Pleumeekers, M. M. (2018, juni 29). Face it: Cell-based therapy for the reconstruction of cartilage defects in the head and neck area. Prom./coprom.: Prof. Dr. G.J.V.M. van Osch & KS Stok. https://repub.eur.nl/pub/105992

Utomo, L. (2018, september 18). Macrophage Phenotypes in Degenerative Joint Diseases. Prom./coprom.: Prof. Dr. G.J.V.M. van Osch, Prof. Dr. J.A.N. Verhaar & Dr. Y.M. Bastiaansen-Jenniskens. https://repub.eur.nl/pub/106448

Boersema, G.S.A. (2017, September 13). Major Abdominal Surgical Complications : Innovative Approaches. Supervisor(s): Prof. Dr. J.F. Lange, Prof. Dr. G.J. Kleinrensink, Dr. Y.M. Bastiaansen-Jenniskens & Prof.Dr. J. Jeekel. - https://repub.eur.nl/pub/100857

Dorleijn, D.M.J. (2017, January 25). Hip Osteoarthritis : symptomatic presentation and non-operative treatment. Supervisor(s): Prof. Dr. S.M.A. Bierma-Zeinstra, Dr. P.A.J. Luijsterburg & Dr. P.K. Bos. - https://epubs.ogc.nl/?epub=d.dorleijn%20(Metis)

Grotenhuis, N. (2017, October 11). New Models for Patient-specific Evaluation of the Effect of Biomaterials on Macrophages. Supervisor(s): Prof. Dr. G.J.V.M. van Osch, Prof. Dr. J.F. Lange & Dr. Y.M. Bastiaansen-Jenniskens. - https://repub.eur.nl/pub/101852

Vos, BC de (2017, February 7). Battling Obesity : Efforts in preventing knee osteoarthritis. Supervisor(s): Prof. Dr. S.M.A. Bierma-Zeinstra & Dr. J. Runhaar. - https://repub.eur.nl/pub/95488

Wei, W. (2017, October 20). Adipose tissue and the knee? : role of inflammation on joint degeneration and cartilage repair. Supervisor(s): Prof. Dr. G.J.V.M. van Osch, Prof. Dr. J.A.N. Verhaar & Dr. Y.M. Bastiaansen-Jenniskens. - https://repub.eur.nl/pub/102357

Windt, A.E. van der (2017, March 29). Calcineurin Inhibition at Physiological Osmolarity: Toward improving cartilage regeneration. EUR (209 pag.) Supervisor(s): Prof. Dr. Ir. H.H. Weinans & Prof. Dr. J.A.N. Verhaar. - https://repub.eur.nl/pub/98466

Kroon, L. de (2017, October 23). A dive into TGHß signaling components during generation and degeneration of cartilage. Supervisors; van der Kraam PM, Van Osch GJVM, Narcisi R, Blaney Davidson N. - No link available

Connective Tissue Repair Lab

News, events and awards

Our news

Upcoming defense:

September 4, 2024 Sabine van der Graaff. Entitled: 'Clinical Decisions and Implications for Treatment of Anterior Cruciate Ligament Ruptures and Traumatic Meniscal Tears'.
Promotor: Prof. J.A.N. Verhaar, MD, PhD

CoPromotor: D.E. Meuffels, MD, PhD & M. Reijman, PhD

September 17, 2024, 10.30 Queridozaal: Maarten Koper. Entitled: 'Metal-on-Metal Hip Arthroplasty: The significance of component positioning, serum metal ion levels and a lifelong follow up'.
Promotor: Prof. J.A.N. Verhaar, MD, PhD

Copromotor: P.K. Bos, MD. PhD, N. Mathijssen, MD. PhD

September 18, 2024, 10.30 Querido zaal: Kyra Cloosterman. Entitled: On the Run for Running-Related Injuries, Consequences, role of training load and prevention
Promotor: Prof. S.M.A. Bierma-Zeinstra, MD. PhD

Copromotor: R.J. deVos, MD, PhD

September 20, 2024: Noortje Riedstra. Entitled: Hip Morphology and Osteoarthritis, From Anatomical Variations to Clinical Implications
Promotor: Prof.dr. D. Eygendaal & Prof.dr. S.M.A. Bierma-Zeinstra

CoPromotor: R. Agricola, MD, PhD

September 20, 2024: Rik Molenaars: Entitled: Ulnar Collateral Ligament Insufficiency of the Elbow in Overhead Athletes
Promotor: Prof.dr. D. Eygendaal & Prof.dr. M.P.J. van den Bekerom

October 15, 2024, 15.30 Querido zaal: Tjerk Visser Sleeswijk; Entitled: Impact, diagnostic imaging and prognosis of Achilles tendinopathy
Promotor: Prof. Eygendaal, MD, PhD

Copromotor: R.J. de Vos, MD, PhD